Description
General Description
4-Arm PEG-Succinamic Acid is a branched PEG derivative functionalized with four terminal succinamic acid groups. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced conjugation efficiency, and improved crosslinking capability.
The terminal carboxylic acid groups can be activated using EDC, NHS, DCC, or related coupling chemistries for conjugation with amine-containing peptides, proteins, antibodies, polymers, nanoparticles, and biomaterial surfaces. The succinamic acid linker introduces an amide bond between the PEG backbone and terminal carboxyl group, providing improved hydrolytic stability compared with ester-linked analogs.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption. 4-Arm PEG-SAA is widely employed in hydrogel preparation, tissue engineering scaffolds, protein immobilization, drug delivery systems, nanoparticle functionalization, and advanced biomaterials development.
Applications
- Hydrogel synthesis
- Tissue engineering
- Drug delivery systems
- Protein conjugation
- Peptide conjugation
- Antibody conjugation
- Surface modification
- Nanoparticle functionalization
- Biomaterials engineering
- Biomedical research
Features and Benefits
- Four terminal succinamic acid groups
- Multiple reactive carboxylic acid groups
- Multi-arm PEG architecture
- Amide-linked terminal functionality
- Compatible with EDC/NHS coupling chemistry
- Excellent water solubility
- Excellent biocompatibility
- Low protein adsorption
- Available in multiple molecular weights
