Product Description
DBCO-Acid (DBCO-COOH) is an amine-reactive non-activated building block used for derivatizing amine-containing molecule in the presence of activators. In the presence of activators such as EDC or DCC, this reagent can be used to derivatize amine-containing molecules through a stable amide bond.
Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cyclo-alkynes for strain-promoted alkyne azide cycloaddition (SPAAC) – a copper-free click chemistry reaction.
DBCO reacts instantly with azide containing molecules. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines – this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.
This amine-reactive NHS ester provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.
