Polymeric micelles have been widely studied and developed for targeted delivery of cytostatic drugs. However, due to heterogeneity of tumor cells, targeting efficiency may be enhanced by using different types of targeting agents on the same drug delivery system. Recently, one study published in Materials Letters developed dual targeted micelles for anticancer drug delivery. The aim of the study was to obtain and characterize paclitaxel-loaded biodegradable poly(L-lactide)-co-poly(ethylene glycol) (PLA-PEG) micelles functionalized with folic acid and biotin (Nanosoft Polymers). The developed dual targeted micelles show low critical micelle concentration, high loading capacity of paclitaxel and prolonged in vitro drug release. The cytotoxicity of paclitaxel-loaded micelles was confirmed against folate- and biotin-receptor positive OVCAR3 cells, which indicates their usefulness for targeted delivery of cytostatic drug. Materials Letters 241 (2019) 187-189.
