About NSP

Nanosoft Polymers (NSP)  specializes in  bridging the gap betwepolymer1en polymer and drug delivery by supplying ready-to-use functionalized polymer & copolymers  for use in therapeutics, devices and diagnostics.

homepage-pic2NSP manufactures and sells a unique collection of functional polymers,  copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification.

NSP also specializes in  polymer synthesis and functionalization, nanoparticle fabrication, surface modification, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights. 

Our Mission

We are dedicated to building a long-term, trusting relationship with our customers  by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support.

High quality We guarantee the superior quality of our products by providing real analytical data  with excellent lot-by-lot reproducibility.

Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too.

Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers.

Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors.

Professional support We provide the highest level of technical support to our customers. 

Fast turnaround  Our experienced team work together to make sure quick turnaround for your orders.

New products

Nanosoft Polymers offers polysarcosine , which is an endogenous and has previously shown potent stealth properties.

Nanosoft Polymers offers PEG-poly(α-benzyl carboxylate-ε-caprolactone), which has functional side groups on the polyester block for micelle core modification!

Nanosoft Polymers offers multi-arm PLGAs for drug delivery  and biomedical research! 

Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification! 

Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery!

Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!


Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry!

Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"!

Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery! 

Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery!

Nanosoft Polymers offers custom synthesis for your special demand. Please contact us!

 

NSP Products In Literature

Nanosoft Polymers’s functional lipid has been used to develop HER2 targeted liposomes for cancer therapy

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HER2 is a biomarker of human breast cancer has become an important validated therapeutic target in breast cancer. Recently, a research published in Theranostics using OBOC to screen  a library of novel HER2 targeting peptides. These targeting peptides were conjugated to DSPE-PEG-Maleimide (Nanosoft Polymers) to develop HER2 targeted liposomes for doxorubicin delivery to improve the cancer therapy and diagnosis.  Geng L. et al. HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery. Theranostics. 2016: 6(8): 1261-1273.

NSP’s DSPE-PEG-Mal were used for Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery

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Polyethylenimine (PEI) as a cationic polymer is commonly used as a carrier for gene delivery. PEI-800 is less toxic than PEI-25K but it is also less efficient. A novel nanocarrier was developed by combining PEI-800 with a pH-sensitive lipid to form polymer-lipid hybrid nanoparticles (P/LNPs). They were synthesized by microfluidic focusing (MF). Two microfluidic devices were used to synthesize P/LNPs loaded with VEGF siRNA. A series of P/LNPs with different particle sizes and distributions were obtained by altering the flow rate and geometry of microfluidic chips, and introducing sonication. Furthermore, the P/LNPs can be loaded with VEGF siRNA efficiently and were stable in serum for 12 h. Finally, P/LNPs produced by the microfluidic chip showed greater cellular uptake as well as down-regulation of VEGF protein level in both A549 and MCF-7 with reduced cellular toxicity. All in all, the P/LNPs produced by MF method were shown to be a safe and efficient carrier for VEGF siRNA, with potential application for siRNA therapeutics. Molecules 2016, 21(10), 1314; https://doi.org/10.3390/molecules21101314