About NSP
Nanosoft Polymers (NSP) specializes in bridging the gap betwe
en polymer and drug delivery by supplying ready-to-use functionalized polymer & copolymers for use in therapeutics, devices and diagnostics.
NSP manufactures and sells a unique collection of functional polymers, copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification.
NSP also specializes in polymer synthesis and functionalization, nanoparticle fabrication, surface modification, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights.
Our Mission
We are dedicated to building a long-term, trusting relationship with our customers by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support.
High quality We guarantee the superior quality of our products by providing real analytical data with excellent lot-by-lot reproducibility.
Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too.
Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers.
Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors.
Professional support We provide the highest level of technical support to our customers.
Fast turnaround Our experienced team work together to make sure quick turnaround for your orders.
New products
Nanosoft Polymers offers polysarcosine , which is an endogenous and has previously shown potent stealth properties.
Nanosoft Polymers offers PEG-poly(α-benzyl carboxylate-ε-caprolactone), which has functional side groups on the polyester block for micelle core modification!
Nanosoft Polymers offers multi-arm PLGAs for drug delivery and biomedical research!
Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!
Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery!
Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!
Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!
Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!
Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry!
Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"!
Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery!
Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery!
Nanosoft Polymers offers custom synthesis for your special demand. Please contact us!
NSP Products In Literature
NSP’s Polymer were used in a patent for formulation of insoluble camptothecin compound with double core-shell structure
Recently, An patent (US20180369231A1) published by SNBioScience Inc. has invented a drug delivery system having a double core-shell structure and, specifically, to a double nano-drug delivery system having an inner core-shell containing a poorly soluble camptothecin compound and a water-soluble camptothecin compound inside and an amphiphilic polymer shell, and to a manufacturing method therefor. The double core-shell structured particles manufactured by the present invention form very stable particles and show a mono-distribution of particles before and after freeze-drying. The particles of the present invention show excellent results compared with existing monolayer micelles in animal efficacy tests and pharmacokinetic tests, and do not use a surfactant causing hypersensitivity, and thus the use of the particles of the present invention can provide a pharmaceutical composition or a drug delivery system platform, which are safe for the human body. NSP’s polymers were used in the formulation. (https://patents.google.com/patent/US20180369231A1/en).
NSP’s DSPE-PEG-Mal were used to develop MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy
Nanoparticle (NP)-based tumor theranostics have ushered in new opportunities for personalized nanomedicine due to their rational design and functionalization. Through the active-peptide-functionalization, a research group developed a nanoscale micelles system (named HEKM) which consists of tumor microenvironment-regulated shape-changing with specific recognition abilities for enhanced cellular targeting, internalization and therapy of heterogeneic tumors. As a result, HEKMs could recognize and bind the tumor heterogeneity marker EGFR-HER2 complex, which led to an enhanced tumor targeting effect. In particular, HEKMs could self-assemble into nanorods under normal physiological conditions while transform into nanospheres in the tumor extracellular microenvironment by a sensitive response to matrix metalloproteinase-2 (MMP-2). The nanorods could prolong the blood circulation time while the nanospheres could accelerate tissue penetration in tumors. In vivo dual-modal targeted imaging was realized by FRET-fluorophore conjugation and gadolinium loading in HEKMs. Tumor cell apoptosis was achieved by proapoptotic element integration. The in vitro and in vivo studies both demonstrated that these rationally designed, shape-changing and targeting micelles could achieve maximized drug efficacy and minimum side effects. Theranostics 2019; 9(6): 1728-1740. doi: 10.7150/thno.30915.