About NSP

Nanosoft Polymers (NSP)  specializes in  bridging the gap betwepolymer1en polymer and drug delivery by supplying ready-to-use functionalized polymer & copolymers  for use in therapeutics, devices and diagnostics.

homepage-pic2NSP manufactures and sells a unique collection of functional polymers,  copolymers, and polymer conjugates. NSP's polymer catalog includes functional PLGA-PEG, PLA-PEG, PCL-PEG, lipid-PEGs, poly(L-lysine)-PEG, poly(L-glutamic acid)-PEG and pegylation reagents that can be used in your research involving drug/gene delivery, encapsulation, cell adhesion and surface modification.

NSP also specializes in  polymer synthesis and functionalization, nanoparticle fabrication, surface modification, and custom synthesis of reactive oligomers and polymers with a broad range of molecular weights. 

Our Mission

We are dedicated to building a long-term, trusting relationship with our customers  by offering quality functional polymers and copolymers backed up with exceptional customer service and technical support.

High quality We guarantee the superior quality of our products by providing real analytical data  with excellent lot-by-lot reproducibility.

Quick delivery We keep catalog items in stock. Overnight delivery is possible in US. Delivery is quick to other worldwide locations, too.

Simple payment We accept NET 30 days payments, Credit cards, checks, and wire transfers.

Great pricing We provide excellent pricing for our products. Check out our catalog now and compare the prices with our competitors.

Professional support We provide the highest level of technical support to our customers. 

Fast turnaround  Our experienced team work together to make sure quick turnaround for your orders.

New products

Nanosoft Polymers offers polysarcosine , which is an endogenous and has previously shown potent stealth properties.

Nanosoft Polymers offers PEG-poly(α-benzyl carboxylate-ε-caprolactone), which has functional side groups on the polyester block for micelle core modification!

Nanosoft Polymers offers multi-arm PLGAs for drug delivery  and biomedical research! 

Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification! 

Nanosoft Polymers offers functionalized PEI-PEGs for in vitro and in vivo gene delivery!

Nanosoft Polymers offers Functional linear polyamino acids for drug delivery and surface modification!


Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

Nanosoft Polymers offers Folate-PEG-PLA/PLGAfor targeted nanoparticles!

Nanosoft Polymers offers DSPE-PEG-DBCO for copper-free click chemistry!

Nanosoft Polymers offers DSPE-PEG-Azide for bioconjugation by "click chemistry"!

Nanosoft Polymers offers PLGA-PEG-Maleimide, and PLGA-PEG-Amine for gene/drug delivery! 

Nanosoft Polymers offers Azide-PEG-PLL and Azide-PEG-pAsp for gene/drug delivery!

Nanosoft Polymers offers custom synthesis for your special demand. Please contact us!

 

NSP Products In Literature

Nanosoft Polymers’s lipid were used in Construction of Antithrombotic Tissue-Engineered Blood Vessel via Reduced Graphene Oxide Based Dual-Enzyme Biomimetic Cascade

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Thrombosis is one of the biggest obstacles in the clinical application of small-diameter tissue-engineered blood vessels (TEBVs). The implantation of an unmodified TEBV will lead to platelet aggregation and further activation of the coagulation cascade, in which the high concentration of adenosine diphosphate (ADP) that is released by platelets plays an important role. A research paper published in ACS Nano reported a reduced graphene oxide (RGO) based dual-enzyme biomimetic cascade to successively convert ADP into adenosine monophosphate (AMP) and AMP into adenosine. The enzymes were linked to RGO via the amphipathic molecule DSPE-PEG2000-COOH (Nanosoft Polymers). The strong hydrophobic force between the DSPE chain and hydrophobic RGO tightly immobilized DSPE-PEG2000-COOH on the surface of the RGO, and the hydrophilic PEG chain provided the RGO with good water dispersibility and biocompatibility. The  experimental results demonstrate that the two enzymes can synergistically catalyze procoagulant ADP into anticoagulant AMP and adenosine successively under physiological conditions, thus reducing the concentration of ADP.  2017 Nov 28;11(11):10964-10973. doi: 10.1021/acsnano.7b04836. Epub 2017 Oct 20.

Nanosoft Polymers’s FITC-labeled polyesters were used in nanoparticles for codelivery of Paclitaxel and Everolimus for the treatment of breast cancer

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Clinical studies examining the combination of paclitaxel (PTX) and everolimus (EVER), an mTOR inhibitor, have failed to result in significant improvements in efficacy and toxicity in patients with breast cancer (BC), relative to treatment with PTX alone. Recently, a research paper published in Molecular Pharmaceutics reported co-delivery of Paclitaxel and Everolimus by polymeric micelles at an optimal synergistic ratio to achieve specific, colocalized delivery of the combination therapy in BC cell lines. The nanoparticles were prepared from PLGA-PEG and PLGA-PEG-FITC (Nanosoft Polymers) had an average diameter of less than 100 nm and were capable of in vitro retention of the encapsulated PTX and EVER at the optimal synergistic molar ratio for over 7 days. The uptake of FITC-labeled NPs in SKBR3 cells was evaluated by flow cytometry, with approximately 41% of cells demonstrating detectable fluorescence after 24 h of exposure. The thorough and systematic approach used in this study to determine and evaluate a synergistic PTX:EVER ratio in conjunction with a potentially promising delivery vector for the drug combination could offer a future clinical benefit for patients with BC.   2018 Jun 14. doi: 10.1021/acs.molpharmaceut.8b00217.