Product Description
Aldehyde-PEG-Aldehyde (ALD-PEG-ALD) is a linear bifunctional crosslinking PEG reagent with one aldehyde at both ends of PEG. Aldehyde reacts with amine and N-terminal of peptide and protein to form an imine containing a C=N double bond, which can be further reduced to a more stable C-N bond. PEG aldehyde or ketone derivatives can be used in reversible PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrazone linkage.
