Product Description

DSPE-PEG-Vinylsulfone (DSPE-PEG-VS) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a biotin. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle which has functional vinylsulfone on the surface that can react with thiol-containing peptides or antibodies. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the VS group to bind to targeting molecules including antibody, aptamer, protein, and peptide.