Description
General Description
Cholesterol-mPEG is a versatile lipid-PEG conjugate designed for membrane anchoring and nanoparticle stabilization. The cholesterol moiety readily incorporates into liposomal membranes, lipid nanoparticles (LNPs), micelles, and other lipid-based delivery systems, while the hydrophilic mPEG chain extends into the aqueous environment, creating a protective steric barrier.
The mPEG segment reduces protein adsorption, minimizes opsonization, and improves colloidal stability, resulting in enhanced circulation time and improved in vivo performance. Cholesterol-mPEG is widely used in liposome engineering, nanoparticle formulation, drug delivery systems, gene delivery platforms, and nanomedicine applications.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Drug delivery systems
- Gene delivery
- mRNA delivery systems
- Nanoparticle stabilization
- Long-circulating liposomes
- Pharmaceutical formulations
- Nanomedicine research
- Biomaterials development
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic mPEG spacer improves biocompatibility
- Enhances nanoparticle stability
- Reduces protein adsorption and opsonization
- Extends circulation time
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Excellent membrane compatibility
