Description
General Description
Cholesterol-PEG-COOH is a versatile lipid-PEG conjugate designed for membrane anchoring and biomolecule conjugation. The cholesterol segment readily inserts into liposomal membranes and lipid nanoparticle formulations, while the PEG chain extends into the aqueous environment, improving colloidal stability and reducing nonspecific interactions.
The terminal carboxyl group can be activated using EDC/NHS chemistry for conjugation to peptides, proteins, antibodies, fluorophores, nucleic acids, and targeting ligands. Cholesterol-PEG-COOH is widely used in liposome engineering, targeted nanomedicine, diagnostic applications, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Nanomedicine research
- Diagnostic applications
- Biomolecule immobilization
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive carboxyl group for versatile conjugation
- Compatible with EDC/NHS coupling chemistry
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
