Description
General Description
Cholesterol-PEG-NHS is a versatile lipid-PEG conjugate designed for membrane anchoring and biomolecule conjugation. The cholesterol segment readily inserts into liposomal membranes and lipid nanoparticle formulations, while the PEG chain extends into the aqueous environment, improving colloidal stability and reducing nonspecific interactions.
The terminal NHS ester group reacts rapidly with amine-containing molecules under mild conditions to form stable amide bonds. This enables efficient conjugation of peptides, proteins, antibodies, fluorophores, nucleic acids, and targeting ligands. Cholesterol-PEG-NHS is widely used in liposome engineering, targeted nanomedicine, diagnostic applications, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Amine conjugation
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Nanomedicine research
- Diagnostic applications
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive NHS ester for efficient amine coupling
- Rapid formation of stable amide bonds
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
