Description
General Description
Cholesterol-PEG-SH is a versatile lipid-PEG conjugate designed for membrane anchoring and biomolecule conjugation. The cholesterol segment readily inserts into liposomal membranes and lipid nanoparticle formulations, while the PEG chain extends into the aqueous environment, improving colloidal stability and reducing nonspecific interactions.
The terminal thiol group reacts efficiently with maleimides, vinyl sulfones, acrylates, gold surfaces, and other thiol-reactive molecules, enabling attachment of peptides, proteins, antibodies, fluorophores, nucleic acids, and targeting ligands. Cholesterol-PEG-SH is widely used in liposome engineering, targeted nanomedicine, diagnostic applications, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Thiol-maleimide conjugation
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Gold nanoparticle functionalization
- Nanomedicine research
- Surface modification
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive thiol group for versatile conjugation
- Compatible with maleimide coupling chemistry
- Enables disulfide bond formation
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Available in multiple PEG molecular weights
