DSPE-PEG-NHS

Description

General Description

DSPE-PEG-NHS is a phospholipid–poly(ethylene glycol) conjugate containing DSPE (distearoyl phosphoethanolamine), a hydrophilic PEG spacer, and a terminal NHS ester functional group. The NHS ester readily reacts with primary amines to form stable amide bonds under mild conditions.

Key Properties

• NHS ester-functionalized lipid PEG conjugate
• Reactive toward primary amines
• DSPE lipid anchor for membrane incorporation
• PEG spacer improves aqueous solubility and steric stabilization
• Biocompatible lipid–polymer hybrid material

Applications

• Liposome and lipid nanoparticle functionalization
• Amine-reactive bioconjugation
• Surface modification of nanoparticles and biomaterials
• Targeted drug delivery system development
• Protein and antibody conjugation
• Hydrogel and polymer functionalization

Functional Overview

The DSPE lipid segment anchors into lipid bilayers, while PEG provides flexibility and stealth properties. The terminal NHS ester reacts efficiently with amine-containing molecules to enable stable conjugation and surface functionalization.

Summary

DSPE-PEG-NHS is a versatile amine-reactive lipid PEG conjugate widely used in liposome engineering, bioconjugation, and advanced drug delivery applications.