Description
General Description
Cholesterol-PEG-Biotin is a versatile lipid-PEG conjugate designed for membrane anchoring and biological recognition. The cholesterol segment readily inserts into liposomal membranes and lipid nanoparticle formulations, while the PEG chain extends into the surrounding aqueous environment, improving colloidal stability and reducing nonspecific interactions.
The terminal biotin functionality enables highly specific interactions with streptavidin and avidin, facilitating the attachment of antibodies, proteins, peptides, fluorophores, nucleic acids, and other biomolecules. Cholesterol-PEG-Biotin is widely used in targeted nanomedicine, biosensing, imaging, diagnostics, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Streptavidin-mediated conjugation
- Targeted drug delivery
- Antibody immobilization
- Protein conjugation
- Diagnostic assay development
- Bioseparation applications
- Nanomedicine research
- Surface modification
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Biotin group enables strong streptavidin/avidin binding
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- High-affinity biological recognition functionality
- Available in multiple PEG molecular weights
