Description
General Description
Cyclosporin A (CsA) is a hydrophobic cyclic peptide originally isolated from the fungus Tolypocladium inflatum. It selectively inhibits calcineurin, thereby blocking the activation of T lymphocytes and reducing the production of pro-inflammatory cytokines. Due to its potent immunosuppressive activity, Cyclosporin A has become one of the most extensively studied compounds in transplantation medicine and autoimmune disease research.
Owing to its poor aqueous solubility, Cyclosporin A is frequently incorporated into liposomes, polymeric nanoparticles, lipid nanoparticles (LNPs), micelles, hydrogels, and other nanocarrier systems to improve solubility, bioavailability, and targeted delivery. It is also widely used as a model hydrophobic drug for evaluating novel drug delivery platforms.
Applications
- Drug delivery research
- Nanoparticle formulation
- Liposome development
- Lipid nanoparticle (LNP) research
- Immunology research
- Transplantation research
- Autoimmune disease research
- Pharmaceutical formulation development
- Controlled drug delivery
- Biomaterials research
Features and Benefits
- Potent calcineurin inhibitor
- Well-characterized immunosuppressant
- Model hydrophobic drug
- Suitable for liposome and nanoparticle formulations
- High pharmaceutical purity
- Widely cited in biomedical literature
- Useful for formulation optimization
- Suitable for research applications
