Description
DSPE-PEG-Biotin (DSPE-PEG-BIO)
DSPE-PEG-Biotin (DSPE-PEG-BIO) is a linear heterobifunctional PEGylation reagent composed of a hydrophobic DSPE phospholipid and a hydrophilic polyethylene glycol (PEG) chain terminated with a biotin functional group.
This amphiphilic structure enables self-assembly into liposomes and micelles, making it a versatile building block for PEGylated lipid-based nanocarriers.
The DSPE lipid anchors into lipid bilayers, while the PEG segment enhances colloidal stability, aqueous solubility, and prolonged systemic circulation. The terminal biotin group enables strong non-covalent binding to avidin or streptavidin, providing a highly specific and widely used bioconjugation strategy.
Key Applications
- Preparation of PEGylated liposomes and micelles
- Targeted drug and gene delivery systems
- Surface functionalization of lipid nanoparticles
- Avidin/streptavidin-based bioconjugation
- Attachment of targeting ligands (antibodies, peptides, proteins, aptamers)
Functional Advantages
- Self-assembling amphiphilic lipid–PEG structure
- Improves nanoparticle stability and drug solubility
- Extends blood circulation time via PEGylation
- Enables high-affinity biotin–avidin interaction
- Supports versatile and modular surface functionalization
Summary
DSPE-PEG-BIO is a multifunctional lipid–PEG conjugate designed for stable PEGylated nanocarriers and highly specific biotin–avidin-mediated targeting in drug delivery and biomedical applications.
