DSPE-Polysarcosine lipid polymer structure

DSPE-pSar (DSPE-Polysarcosine)

Price range: $480.00 through $1,800.00

DSPE-pSar (DSPE-Polysarcosine) is an amphiphilic lipid-polypeptoid conjugate consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) linked to polysarcosine. The polysarcosine segment provides excellent water solubility, low protein adsorption, and stealth properties, making DSPE-Polysarcosine an attractive alternative to PEGylated lipids for liposome formulation, lipid nanoparticles, drug delivery, and nanomedicine applications.

Product Specifications

Product Name: DSPE-Polysarcosine
Polymer Composition: DSPE-Poly(N-methylglycine)
Molecular Weight: 350 (n=5), 700 (n=10),  1400 (n=20),  3500 (n=50), 7000 (n=100), 10.6K (n=150), Custom available
CAS Number: 3091879-29-4
Functional Groups: DSPE, Polysarcosine
Appearance: White to off-white solid
Solubility: Water, PBS, Methanol, DMSO
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

DSPE-Polysarcosine lipid polymer structure
n:         5          10             20              50          100            150
MW:  350       700        1400          3500       7000        10650

 

SKU: 26665 Categories: , , ,

Description

General Description

DSPE-pSar (DSPE-Polysarcosine) is a lipid-polypeptoid conjugate designed for membrane anchoring and nanoparticle stabilization. The DSPE lipid anchor readily incorporates into liposomal membranes, lipid nanoparticles (LNPs), micelles, and other lipid-based delivery systems, while the polysarcosine chain extends into the aqueous environment to create a hydrophilic protective layer.

Polysarcosine is a biocompatible and biodegradable polypeptoid derived from N-methylglycine that exhibits low protein adsorption, low immunogenicity, and excellent aqueous solubility. As a result, DSPE-Polysarcosine can provide stealth-like properties comparable to PEGylated lipids while offering an alternative polymer platform for advanced drug delivery systems. The material is widely used in liposome engineering, mRNA delivery, nanoparticle stabilization, and nanomedicine research.

Applications

  • Liposome formulation
  • Lipid nanoparticle (LNP) development
  • mRNA delivery systems
  • Drug delivery systems
  • Gene delivery
  • Nanoparticle stabilization
  • Long-circulating nanocarriers
  • Nanomedicine research
  • Biomaterials development
  • Surface modification

Features and Benefits

  • DSPE anchor for membrane incorporation
  • Polysarcosine stealth polymer coating
  • Excellent aqueous solubility
  • Low protein adsorption
  • Low immunogenicity
  • Biocompatible and biodegradable
  • Alternative to PEGylated lipids
  • Improves nanoparticle stability
  • Suitable for liposomes and LNPs

Additional information

Molecular Weight

700, 1400, 2800, 3500, 7000, 10.6K, 14K
Package Size

50mg, 100mg, 500mg, 1g

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