Poly(L-Aspartic Acid)-PEG-N₃ (pAsp-PEG-N₃)

Description

General Description

Poly(L-Aspartic Acid)-PEG-N₃ is a multifunctional amphiphilic block copolymer designed for bioorthogonal conjugation and advanced drug delivery applications. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, enabling highly selective conjugation under mild conditions.

The biodegradable poly(L-aspartic acid) segment contains multiple pendant carboxylic acid groups that can be activated using EDC/NHS chemistry for conjugation with proteins, peptides, antibodies, drugs, nanoparticles, and imaging agents. The PEG segment improves water solubility, biocompatibility, circulation time, and reduces nonspecific protein adsorption.

The combination of a biodegradable pAsp block, a hydrophilic PEG spacer, and a terminal azide group makes pAsp-PEG-N₃ an excellent material for polymer-drug conjugates, targeted nanoparticles, hydrogels, molecular imaging, and advanced biomaterials.

Applications

• Click chemistry (CuAAC)
• Copper-free click chemistry (SPAAC)
• Drug conjugation
• Polymer-drug conjugates
• Nanoparticle functionalization
• Hydrogel synthesis
• Protein and peptide conjugation
• Surface modification
• Molecular imaging
• Biomaterials research

Features and Benefits

• Terminal azide functionality
• Amphiphilic block copolymer
• Biodegradable poly(L-aspartic acid) segment
• Hydrophilic PEG spacer
• Multiple pendant carboxylic acid groups
• Compatible with CuAAC and SPAAC chemistry
• Compatible with EDC/NHS coupling
• Available in multiple polymer compositions