Description
General Description
PLGA-NH₂ (75:25) is a biodegradable polyester synthesized from D,L-lactide and glycolide with a 75:25 monomer ratio and terminated with a primary amine group. The higher lactide content provides slower degradation and increased hydrophobicity compared to lower lactide PLGA compositions, making the polymer particularly suitable for sustained drug release applications.
The terminal amine group readily reacts with activated esters, carboxylic acids, aldehydes, isocyanates, and other amine-reactive compounds, enabling efficient bioconjugation and polymer functionalization. PLGA-NH₂ (75:25) is widely used for the preparation of functional nanoparticles, polymer-drug conjugates, targeted delivery systems, and advanced biomaterials.
Applications
- Drug delivery systems
- Nanoparticle preparation
- Controlled drug release
- Peptide conjugation
- Protein conjugation
- Antibody conjugation
- Surface modification
- Tissue engineering
- Biomaterials research
- Polymer functionalization
Features and Benefits
- Reactive primary amine functionality
- Biodegradable and biocompatible
- 75:25 lactide:glycolide composition
- Slower degradation profile than 50:50 PLGA
- Compatible with NHS ester coupling chemistry
- Suitable for biomolecule conjugation
- Excellent drug delivery carrier
- Supports nanoparticle fabrication
- Available in multiple molecular weights
