Description

General Description

Cholesterol-PEG-OH consists of a cholesterol anchor attached to a polyethylene glycol chain terminated with a hydroxyl group. The cholesterol segment can readily incorporate into lipid membranes and lipid-based nanocarriers, while the PEG chain extends into the aqueous environment, reducing aggregation and improving colloidal stability.

The terminal hydroxyl group can serve as a precursor for further chemical modification and synthesis of functional cholesterol-PEG conjugates. Cholesterol-PEG-OH is commonly employed in liposome engineering, lipid nanoparticle formulation, targeted drug delivery systems, and biomaterials research.

Applications

• Liposome formulation and stabilization
• Lipid nanoparticle (LNP) development
• Drug delivery systems
• Membrane and surface modification
• Nanomedicine research
• Gene and nucleic acid delivery
• Biomaterials engineering
• Preparation of functional cholesterol-PEG derivatives
• Cell membrane studies
• Controlled release formulations

Features and Benefits

• Cholesterol anchor enables membrane incorporation
• Hydrophilic PEG spacer improves aqueous solubility
• Enhances nanoparticle stability and circulation properties
• Reduces nonspecific interactions
• Hydroxyl group available for further functionalization
• Suitable for lipid-based drug delivery systems
• Available in multiple PEG molecular weights