Description
General Description
4-Arm PLGA-SH is a multifunctional biodegradable polyester designed for advanced drug delivery and biomedical applications. The polymer consists of four PLGA chains radiating from a central core, with each arm terminating in a reactive thiol group.
The thiol functionalities readily react with maleimides, vinyl sulfones, acrylates, gold surfaces, and other thiol-reactive molecules, enabling efficient conjugation of peptides, proteins, antibodies, targeting ligands, fluorophores, and other biomolecules. Compared with linear PLGA derivatives, the multi-arm architecture provides significantly higher functional group density, allowing efficient preparation of multifunctional nanoparticles, targeted delivery systems, and crosslinked biomaterials.
Upon hydrolysis, the polymer degrades into lactic acid and glycolic acid, making it suitable for biodegradable pharmaceutical and biomedical applications.
Applications
- Drug delivery systems
- Polymeric nanoparticles
- Targeted drug delivery
- Thiol-maleimide conjugation
- Peptide conjugation
- Antibody conjugation
- Protein conjugation
- Hydrogel formation
- Surface modification
- Nanomedicine research
Features and Benefits
- Star-shaped PLGA architecture
- Multiple terminal thiol groups
- Higher functional group density than linear PLGA
- Versatile thiol conjugation chemistry
- Biodegradable and biocompatible
- Enhanced drug loading capability
- Suitable for nanoparticle and hydrogel fabrication
- Available in multiple molecular weights and PLGA ratios
