Description
General Description
4-Arm PLGA-Biotin is a multifunctional biodegradable polyester designed for advanced drug delivery and biomedical applications. The polymer consists of four PLGA chains radiating from a central core, with each arm terminating in a biotin moiety.
The biotin functionalities enable highly specific interactions with streptavidin and avidin proteins, facilitating efficient attachment of antibodies, proteins, peptides, imaging agents, targeting ligands, and other biomolecules. Compared with linear PLGA derivatives, the multi-arm architecture provides significantly higher biotin density, allowing efficient preparation of multifunctional nanoparticles, targeted delivery systems, and bioactive materials.
Upon hydrolysis, the polymer degrades into lactic acid and glycolic acid, making it suitable for biodegradable pharmaceutical and biomedical applications.
Applications
- Drug delivery systems
- Polymeric nanoparticles
- Targeted drug delivery
- Streptavidin-mediated conjugation
- Antibody immobilization
- Protein conjugation
- Diagnostic assay development
- Bioseparation applications
- Surface modification
- Nanomedicine research
Features and Benefits
- Star-shaped PLGA architecture
- Multiple terminal biotin groups
- Higher functional group density than linear PLGA
- Strong streptavidin/avidin binding affinity
- Biodegradable and biocompatible
- Enhanced drug loading capability
- Suitable for nanoparticle fabrication
- Available in multiple molecular weights and PLGA ratios
