Description
General Description
4-Arm PLGA-NHS is a multifunctional biodegradable polyester designed for advanced drug delivery and biomedical applications. The polymer consists of four PLGA chains radiating from a central core, with each arm terminating in a highly reactive N-hydroxysuccinimide (NHS) ester group.
The NHS ester functionalities rapidly react with amine-containing molecules to form stable amide bonds, enabling efficient conjugation of peptides, proteins, antibodies, targeting ligands, fluorophores, and other biomolecules. Compared with linear PLGA derivatives, the multi-arm architecture provides significantly higher reactive group density, allowing efficient preparation of multifunctional nanoparticles, targeted delivery systems, and crosslinked biomaterials.
Upon hydrolysis, the polymer degrades into lactic acid and glycolic acid, making it suitable for biodegradable pharmaceutical and biomedical applications.
Applications
- Drug delivery systems
- Polymeric nanoparticles
- Targeted drug delivery
- Peptide conjugation
- Antibody conjugation
- Protein conjugation
- Surface modification
- Hydrogel formation
- Controlled drug release
- Nanomedicine research
Features and Benefits
- Star-shaped PLGA architecture
- Multiple terminal NHS ester groups
- Higher functional group density than linear PLGA
- Efficient amine conjugation chemistry
- Rapid formation of stable amide bonds
- Biodegradable and biocompatible
- Suitable for nanoparticle and hydrogel fabrication
- Available in multiple molecular weights and PLGA ratios
