Description
General Description
10-Hydroxycamptothecin (HCPT) is a semi-natural camptothecin analog that exhibits potent antitumor activity through selective inhibition of DNA topoisomerase I. By stabilizing the topoisomerase I-DNA cleavage complex, HCPT prevents DNA religation, resulting in DNA damage, inhibition of DNA replication, and apoptosis of rapidly proliferating tumor cells.
Because of its limited water solubility and lactone ring instability under physiological conditions, HCPT has been extensively investigated in liposomes, polymeric micelles, PEGylated nanoparticles, lipid nanoparticles (LNPs), hydrogels, and other nanocarrier systems to improve its stability, bioavailability, and tumor-targeting capability.
HCPT is widely used in oncology research, nanomedicine, pharmaceutical formulation development, controlled drug delivery, and biomaterials research.
Applications
- Anticancer research
- Drug delivery research
- Liposome formulation
- Polymeric nanoparticle development
- Lipid nanoparticle (LNP) research
- Polymeric micelle formulation
- Controlled drug delivery
- Pharmaceutical formulation development
- Nanomedicine research
- Biomaterials research
Features and Benefits
- Potent topoisomerase I inhibitor
- Broad-spectrum antitumor activity
- Model hydrophobic anticancer drug
- Suitable for liposome and nanoparticle formulations
- High pharmaceutical purity
- Widely used in nanomedicine research
- Useful for formulation optimization
- Suitable for research applications
