Description
General Description
8-Arm PLGA-Biotin is a highly branched biodegradable polyester designed for advanced drug delivery and biomedical applications. The polymer consists of eight PLGA chains attached to a central multifunctional core, creating a star-shaped architecture with multiple terminal biotin groups.
The biotin functionalities enable highly specific interactions with streptavidin and avidin proteins, facilitating the attachment of antibodies, proteins, peptides, fluorophores, nucleic acids, targeting ligands, and other biomolecules. Compared with conventional linear PLGA derivatives, the eight-arm architecture offers substantially higher functional group density and increased versatility for the preparation of multifunctional nanoparticles, targeted delivery systems, bioactive materials, and diagnostic platforms.
Upon hydrolysis, the polymer degrades into lactic acid and glycolic acid, making it suitable for biodegradable pharmaceutical formulations, regenerative medicine, and biomaterials development.
Applications
- Drug delivery systems
- Polymeric nanoparticles
- Polymeric micelles
- Streptavidin-mediated conjugation
- Targeted drug delivery
- Antibody immobilization
- Protein conjugation
- Diagnostic assay development
- Bioseparation applications
- Nanomedicine research
Features and Benefits
- Star-shaped eight-arm PLGA architecture
- Multiple terminal biotin groups
- Higher functional group density than linear PLGA
- Strong streptavidin/avidin binding affinity
- Biodegradable and biocompatible
- Enhanced drug loading capability
- Suitable for nanoparticle and hydrogel fabrication
- Enables multifunctional biomolecule conjugation
