Description
General Description
DSG-PEG is an amphiphilic PEG-lipid designed for the preparation of long-circulating liposomes and lipid nanoparticles. The DSG moiety contains two saturated stearoyl (C18:0) lipid chains that readily incorporate into phospholipid bilayers, providing excellent membrane stability. The hydrophilic PEG chain extends into the surrounding aqueous environment, creating a protective steric barrier that minimizes particle aggregation, reduces opsonization, and enhances systemic circulation.
Compared with conventional phospholipids, PEGylated DSG significantly improves the colloidal stability and pharmacokinetic performance of lipid-based delivery systems. Depending on the terminal functionality of the PEG chain (e.g., methoxy, amine, carboxyl, maleimide, azide, biotin), DSG-PEG can also serve as a versatile platform for surface functionalization and targeted drug delivery.
DSG-PEG is widely employed in liposome engineering, lipid nanoparticle (LNP) formulation, gene delivery, vaccine development, molecular imaging, and biomaterials research.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) preparation
- Drug delivery
- mRNA delivery
- siRNA delivery
- Gene therapy research
- Vaccine development
- Surface PEGylation
- Molecular imaging
- Biomaterials research
Features and Benefits
- Amphiphilic PEG-lipid
- Stable DSG lipid anchor
- Excellent membrane incorporation
- Improves nanoparticle stability
- Extends blood circulation time
- Reduces nonspecific protein adsorption
- Excellent biocompatibility
- Available in multiple PEG molecular weights and terminal functional groups
