Description
General Description
DSPE-PEG-N₃ is a phospholipid–poly(ethylene glycol) conjugate containing DSPE (distearoyl phosphoethanolamine) and a terminal azide group. This structure enables stable lipid bilayer anchoring and bioorthogonal click chemistry functionalization.
Key Properties
- DSPE lipid anchor for membrane incorporation
- PEG spacer improves solubility and steric stabilization
- Terminal azide group for click chemistry
- Suitable for liposome and nanoparticle modification
- Biocompatible lipid–polymer hybrid system
Applications
- Liposome surface functionalization
- Lipid nanoparticle (LNP) formulation
- Click chemistry bioconjugation (CuAAC / SPAAC)
- Targeted drug delivery systems
- Biomaterial surface engineering
- Diagnostic and imaging system development
Functional Overview
The DSPE lipid anchors into lipid bilayers, while PEG provides flexibility and stealth properties. The terminal azide enables selective conjugation with alkyne-functionalized molecules via click chemistry.
Summary
DSPE-PEG-N₃ is a versatile lipid–PEG linker widely used in liposome engineering, nanoparticle functionalization, and bioorthogonal conjugation systems.
