Description
General Description
DSTAP (1,2-Distearoyl-3-trimethylammonium-propane) is a quaternary ammonium cationic lipid containing two saturated C18 stearoyl chains and a permanently positively charged trimethylammonium headgroup. DSTAP is commonly used in liposome preparation, nucleic acid complexation, gene delivery research, and lipid-based drug delivery systems.
The strong positive charge facilitates electrostatic interaction with negatively charged nucleic acids, making DSTAP useful for DNA, RNA, siRNA, and oligonucleotide delivery applications.
General Description
DOSTAP is a synthetic cationic lipid designed for gene delivery, nucleic acid encapsulation, and lipid-based drug delivery applications. The positively charged trimethylammonium headgroup readily interacts with negatively charged DNA, RNA, oligonucleotides, proteins, and cell membranes, facilitating cellular uptake and intracellular delivery.
The two oleoyl chains provide membrane fluidity and promote stable liposome and lipid nanoparticle formation. DOSTAP is frequently used alone or in combination with helper lipids such as DOPE, cholesterol, and PEGylated lipids to prepare transfection reagents, gene delivery systems, and advanced nanomedicine formulations.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) preparation
- Gene delivery
- mRNA delivery
- siRNA delivery
- DNA transfection
- Oligonucleotide delivery
- Drug delivery research
- Vaccine development
- Nanomedicine research
Features and Benefits
- Cationic lipid for nucleic acid complexation
- Efficient DNA and RNA delivery
- Promotes cellular uptake
- Forms stable liposomes and nanoparticles
- Compatible with helper lipids and PEGylated lipids
- Suitable for transfection applications
- High membrane fluidity due to unsaturated lipid chains
- Widely used in drug delivery research
