Description
General Description
DOTMA is a synthetic cationic lipid containing two unsaturated hydrophobic alkyl chains linked through ether bonds to a trimethylammonium head group. The positive charge enables strong electrostatic interactions with negatively charged nucleic acids, resulting in stable lipid-nucleic acid complexes suitable for cellular delivery.
DOTMA has been extensively utilized in liposome formulations, gene transfection studies, nucleic acid delivery systems, and lipid nanoparticle development. Its high transfection efficiency and compatibility with helper lipids make it a valuable component in drug delivery and gene therapy research.
Applications
- DNA transfection
- mRNA delivery
- siRNA and miRNA delivery
- Gene therapy research
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Vaccine delivery systems
- Cell transfection studies
- Drug delivery research
- Nanomedicine applications
Features and Benefits
- Permanently charged cationic lipid
- Efficient nucleic acid complexation
- Promotes cellular uptake
- Widely used for transfection applications
- Suitable for liposome and LNP formulations
- Compatible with helper lipids and PEG lipids
- High purity for research applications
