Description
General Description
DSPE-Maleimide is a reactive phospholipid derivative containing DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine, C18:0) and a terminal maleimide functional group. The maleimide group reacts selectively with thiol-containing molecules under mild conditions to form stable thioether linkages.
Key Properties
- Maleimide-functionalized phospholipid
- Reactive toward thiol-containing molecules
- DSPE phospholipid anchor (C18:0)
- Saturated lipid structure for enhanced membrane stability
- Suitable for liposome and nanoparticle functionalization
Applications
- Liposome surface modification
- Lipid nanoparticle engineering
- Thiol-mediated bioconjugation
- Drug and nucleic acid delivery
- Antibody and peptide conjugation
- Nanomedicine and biomaterial applications
Functional Overview
The DSPE lipid segment provides stable membrane incorporation, while the maleimide functionality enables selective conjugation with thiol-containing biomolecules, peptides, antibodies, and surfaces.
