Description
General Description
Folate-PEG-SH is a heterobifunctional PEG derivative designed for targeted drug delivery and biomolecule conjugation. The folic acid moiety serves as a targeting ligand for folate receptors, which are overexpressed in many tumor cells including ovarian, breast, lung, kidney, colorectal, and cervical cancers.
The PEG spacer improves water solubility, reduces immunogenicity, minimizes nonspecific interactions, and prolongs systemic circulation. The terminal thiol group readily reacts with maleimides, vinyl sulfones, acrylates, gold surfaces, and other thiol-reactive molecules, enabling efficient conjugation to nanoparticles, liposomes, proteins, antibodies, peptides, and imaging agents.
Folate-PEG-SH is commonly employed in targeted nanomedicine, cancer imaging, biosensing, surface engineering, and advanced biomaterials research.
Applications
- Targeted drug delivery
- Cancer-targeting nanoparticles
- Folate receptor-mediated delivery
- Liposome functionalization
- Thiol-maleimide conjugation
- Antibody conjugation
- Peptide conjugation
- Surface modification
- Diagnostic imaging
- Nanomedicine research
Features and Benefits
- Folate receptor-targeting functionality
- Hydrophilic PEG spacer improves biocompatibility
- Reactive thiol group for versatile conjugation
- Compatible with maleimide coupling chemistry
- Enables site-specific bioconjugation
- Improves nanoparticle stability and circulation
- Reduces nonspecific protein adsorption
- Available in multiple PEG molecular weights
