Description
General Description
GAS-PEG-GAS is a homobifunctional polyethylene glycol derivative containing succinimidyl glutamic acid ester (GAS) groups at both PEG termini.
The terminal GAS groups are amine-reactive activated esters that can react with primary amines (NH₂), including lysine residues and N-terminal amines in proteins and peptides, to form stable amide bonds.
Because GAS groups are present at both ends, GAS-PEG-GAS can serve as a bifunctional PEG spacer or crosslinker for connecting two amine-containing molecules while introducing a hydrophilic and flexible PEG segment.
NSP offers GAS-PEG-GAS with different PEG molecular weights for bioconjugation, PEGylation, crosslinking, biomolecule modification, and surface functionalization.
Applications
- Protein PEGylation
- Peptide PEGylation
- Bioconjugation
- Molecular crosslinking
- Protein and peptide modification
- Biomolecule immobilization
- Antibody modification
- Nanoparticle functionalization
- Surface modification
- Hydrogel and biomaterial crosslinking
- Synthesis of PEG conjugates
Features and Benefits
- GAS groups at both PEG termini
- Homobifunctional PEG linker
- Two amine-reactive activated ester groups
- Reacts with primary amines
- Forms stable amide bonds
- Hydrophilic and flexible PEG spacer
- Suitable for protein and peptide PEGylation
- Suitable for crosslinking applications
- Multiple PEG molecular weights available
- Custom molecular weights available
