PDLLA-PEG-COOH Structure

PDLLA-PEG-COOH

Price range: $300.00 through $1,200.00

PDLLA-PEG-COOH (Poly(D,L-lactide)-b-Polyethylene Glycol-Carboxyl) is a tin-free, biodegradable amphiphilic block copolymer consisting of poly(D,L-lactide) (PDLLA) and polyethylene glycol (PEG) terminated with a carboxylic acid (COOH) group. The hydrophobic PDLLA segment enables drug encapsulation and nanoparticle formation, while the hydrophilic PEG segment improves aqueous solubility and biocompatibility. The terminal carboxyl group provides a versatile reactive site for conjugation with amine-containing molecules, making PDLLA-PEG-COOH ideal for drug delivery, nanoparticle functionalization, and biomaterials research.

Product Specifications

Product Name: PDLLA-PEG-COOH
Polymer Composition: Poly(D,L-lactide)-b-Polyethylene Glycol-Carboxyl
Molecular Weight: Custom PDLLA and PEG molecular weights available
Functional Groups: Carboxyl (COOH)
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, THF, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PDLLA-PEG-COOH Structure

SKU: 24027 Categories: , ,

Description

General Description

PDLLA-PEG-COOH is a tin-free biodegradable block copolymer widely used in nanomedicine and controlled drug delivery applications. Due to its amphiphilic structure, the copolymer readily self-assembles into polymeric micelles and nanoparticles with a hydrophobic PDLLA core and a hydrophilic PEG shell.

The terminal carboxyl group can be activated using carbodiimide chemistry (EDC/NHS) for conjugation to peptides, proteins, antibodies, targeting ligands, fluorophores, and other amine-containing molecules. PDLLA-PEG-COOH is frequently employed in the development of targeted drug delivery systems, imaging agents, and functional biomaterials.

Applications

  • Polymeric micelle preparation
  • Nanoparticle fabrication
  • Drug delivery systems
  • Targeted drug delivery
  • Peptide conjugation
  • Antibody conjugation
  • Surface modification
  • Controlled drug release
  • Nanomedicine research
  • Biomaterials engineering

Features and Benefits

  • Tin-free synthesis process
  • Biodegradable PDLLA block
  • Hydrophilic PEG segment improves biocompatibility
  • Reactive carboxyl group for further conjugation
  • Self-assembles into nanoparticles and micelles
  • Suitable for hydrophobic drug encapsulation
  • Compatible with EDC/NHS coupling chemistry
  • Available in multiple molecular weight combinations

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10000
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg, 1g

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