PDLLA-PEG-Mal structure

PDLLA-PEG-Mal

Price range: $300.00 through $1,200.00

PDLLA-PEG-Mal (Poly(D,L-lactide)-b-Polyethylene Glycol-Maleimide) is a tin-free, biodegradable amphiphilic block copolymer consisting of poly(D,L-lactide) (PDLLA) and polyethylene glycol (PEG) terminated with a maleimide group. The hydrophobic PDLLA segment enables drug encapsulation and nanoparticle formation, while the hydrophilic PEG segment improves aqueous solubility and biocompatibility. The terminal maleimide group reacts selectively with thiol-containing molecules, making PDLLA-PEG-Mal an excellent material for targeted drug delivery, nanoparticle functionalization, and bioconjugation applications.

Product Specifications

Product Name: PDLLA-PEG-N₃
Polymer Composition: Poly(D,L-lactide)-b-Polyethylene Glycol-Azide
Molecular Weight: Custom PDLLA and PEG molecular weights available
Functional Groups: Azide (N₃)
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, THF, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PDLLA-PEG-Mal structure

SKU: 24076 Categories: , ,

Description

General Description

PDLLA-PEG-Mal is a tin-free biodegradable block copolymer designed for advanced drug delivery and nanomedicine applications. The amphiphilic copolymer self-assembles into polymeric micelles and nanoparticles with a hydrophobic PDLLA core capable of encapsulating hydrophobic therapeutics and a PEG shell that improves stability and circulation properties.

The maleimide functionality enables rapid and selective conjugation with thiol-containing peptides, proteins, antibodies, aptamers, and other targeting ligands under mild conditions. This property makes PDLLA-PEG-Mal particularly useful for preparing actively targeted nanoparticle systems and functional biomaterials.

Applications

  • Polymeric micelle preparation
  • Nanoparticle fabrication
  • Targeted drug delivery
  • Antibody conjugation
  • Peptide conjugation
  • Protein conjugation
  • Surface modification
  • Controlled drug release
  • Nanomedicine research
  • Biomaterials engineering

Features and Benefits

  • Tin-free synthesis process
  • Biodegradable PDLLA block
  • Hydrophilic PEG segment improves biocompatibility
  • Maleimide group for selective thiol coupling
  • Self-assembles into nanoparticles and micelles
  • Suitable for targeted drug delivery
  • Reduces nonspecific protein adsorption
  • Available in multiple molecular weight combinations

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10000
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg, 1g

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