PLGA-PEG-DBCO structure

PLGA-PEG-DBCO

Price range: $360.00 through $1,650.00

PLGA-PEG-DBCO (Poly(lactic-co-glycolic acid)-Polyethylene Glycol-Dibenzocyclooctyne) is a biodegradable amphiphilic block copolymer consisting of PLGA and PEG segments terminated with a dibenzocyclooctyne (DBCO) group. The hydrophobic PLGA segment enables drug encapsulation, while the hydrophilic PEG segment improves aqueous solubility, biocompatibility, and circulation time. The terminal DBCO group enables efficient copper-free click chemistry with azide-containing molecules, making PLGA-PEG-DBCO ideal for targeted drug delivery, nanoparticle functionalization, and nanomedicine research.

Product Specifications

Product Name: PLGA-PEG-DBCO
Polymer Composition: Poly(lactic-co-glycolic acid)-Polyethylene Glycol-Dibenzocyclooctyne
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Functional Groups: DBCO
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, Acetone, THF, Dichloromethane, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PLGA-PEG-DBCO structure

 

SKU: 9765 Categories: , , ,

Description

General Description

PLGA-PEG-DBCO is a functional biodegradable block copolymer that combines the controlled degradation properties of poly(lactic-co-glycolic acid) (PLGA) with the hydrophilicity and stealth characteristics of polyethylene glycol (PEG). The amphiphilic structure readily self-assembles into polymeric micelles and nanoparticles in aqueous environments, making it a widely used material for drug delivery applications.

The terminal DBCO group participates in strain-promoted azide-alkyne cycloaddition (SPAAC), a bioorthogonal copper-free click chemistry reaction that enables efficient conjugation with azide-containing peptides, proteins, antibodies, fluorophores, nucleic acids, targeting ligands, and other biomolecules. PLGA-PEG-DBCO is commonly used in targeted nanomedicine, polymer therapeutics, imaging probes, and advanced biomaterials research.

Applications

  • Polymeric nanoparticle fabrication
  • Polymeric micelle preparation
  • Targeted drug delivery
  • Copper-free click chemistry conjugation
  • Antibody conjugation
  • Peptide conjugation
  • Protein conjugation
  • Surface modification
  • Nanomedicine research
  • Diagnostic and imaging applications

Features and Benefits

  • Biodegradable and biocompatible block copolymer
  • Amphiphilic PLGA-PEG architecture
  • Reactive DBCO functionality
  • Compatible with SPAAC copper-free click chemistry
  • Self-assembles into nanoparticles and micelles
  • Improves drug solubility and stability
  • Prolongs systemic circulation
  • Available in multiple PLGA and PEG molecular weights

Additional information

PLGA Molecular Weight

2K, 5K, 10K, 20K
PEG Molecular Weight

2K, 5K
Package size

100mg, 1g

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