Description
General Description
mPEG-Amine (mPEG-NH2) is one of the most widely used PEGylation reagents for biomedical and pharmaceutical applications. The terminal primary amine group serves as a versatile reactive handle for coupling with proteins, peptides, antibodies, nucleic acids, fluorophores, nanoparticles, polymers, and biomaterial surfaces.
The hydrophilic PEG chain improves water solubility, biocompatibility, circulation time, and stability while reducing immunogenicity and nonspecific protein adsorption. The methoxy terminus prevents undesired crosslinking and provides a stable non-reactive end group.
mPEG-Amine is frequently employed in PEGylated therapeutics, polymer-drug conjugates, nanoparticle surface modification, hydrogel preparation, biomaterials engineering, and synthesis of functional PEG derivatives.
Applications
- PEGylation of proteins and peptides
- Drug delivery systems
- Polymer-drug conjugates
- Nanoparticle functionalization
- Surface modification
- Biomaterials engineering
- Hydrogel synthesis
- Polymer synthesis
- Diagnostic assay development
- Biomedical research
Features and Benefits
- Reactive primary amine functionality
- Monofunctional PEG derivative
- Non-reactive methoxy terminus
- Excellent water solubility
- Improves biocompatibility
- Reduces protein adsorption
- Enhances circulation time
- Suitable for PEGylation applications
- Available in multiple molecular weights
