Description
General Description
PDLLA-Acid (PDLLA-COOH) is a functional aliphatic polyester derived from D,L-lactide. Unlike crystalline PLLA, PDLLA is amorphous, resulting in more uniform degradation behavior and broader applicability in pharmaceutical and biomedical applications.
The terminal carboxylic acid group can be activated using carbodiimide chemistry (EDC, DCC, DIC, NHS) to conjugate peptides, proteins, antibodies, fluorophores, targeting ligands, and other amine-containing molecules. PDLLA-COOH is frequently employed in nanoparticle preparation, polymer-drug conjugates, biodegradable implants, tissue engineering scaffolds, and controlled drug delivery systems.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymer-drug conjugates
- Tissue engineering
- Biodegradable implants
- Surface modification
- Protein conjugation
- Peptide conjugation
- Hydrogel preparation
- Biomaterials research
Features and Benefits
- Biodegradable PDLLA backbone
- Amorphous polymer structure
- Reactive carboxylic acid functionality
- Excellent biocompatibility
- Controlled degradation behavior
- Suitable for bioconjugation
- Easy chemical modification
- Pharmaceutical-grade polymer platform
- Available in multiple molecular weights
