Description
General Description
PDLLA-Amine (PDLLA-NH2) is a functional aliphatic polyester derived from D,L-lactide. Unlike crystalline PLLA, PDLLA is amorphous, resulting in more uniform degradation behavior and broader applicability in pharmaceutical and biomedical applications.
The terminal primary amine group serves as a versatile handle for conjugation with NHS esters, activated carboxylic acids, aldehydes, isothiocyanates, fluorophores, peptides, proteins, antibodies, and targeting ligands. PDLLA-NH2 is frequently employed in nanoparticle preparation, polymer-drug conjugates, biodegradable implants, tissue engineering scaffolds, surface modification, and controlled drug delivery systems.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymer-drug conjugates
- Tissue engineering
- Biodegradable implants
- Surface modification
- Protein conjugation
- Peptide conjugation
- Hydrogel preparation
- Biomaterials research
Features and Benefits
- Biodegradable PDLLA backbone
- Amorphous polymer structure
- Reactive primary amine functionality
- Excellent biocompatibility
- Controlled degradation behavior
- Suitable for bioconjugation
- Easy chemical modification
- Pharmaceutical-grade polymer platform
