Description
General Description
8-Arm PEG NH2 is a multifunctional PEG derivative designed for advanced bioconjugation and hydrogel fabrication. The eight-arm architecture provides a high density of primary amine groups, enabling efficient conjugation to proteins, peptides, antibodies, enzymes, polymers, nanoparticles, and biomaterial surfaces.
The terminal amine groups readily participate in amide bond formation through EDC/NHS coupling with carboxylic acids and react efficiently with NHS esters, aldehydes, epoxides, activated carbonates, and other amine-reactive molecules. The high functionality enables rapid network formation and high crosslinking density, making this polymer particularly suitable for injectable hydrogels, tissue engineering scaffolds, drug delivery systems, and regenerative medicine.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and minimizes nonspecific protein adsorption. Compared with linear PEG derivatives, the eight-arm structure provides superior crosslinking efficiency and enhanced mechanical properties.
Applications
- Hydrogel synthesis
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Surface modification
- Nanoparticle functionalization
- Tissue engineering
- Drug delivery systems
- Cell encapsulation
- Biomaterials research
Features and Benefits
- Eight terminal primary amine groups
- High functional group density
- Efficient amine conjugation
- Compatible with EDC/NHS coupling chemistry
- Excellent water solubility
- Excellent biocompatibility
- High crosslinking efficiency
- Low protein adsorption
- Ideal for hydrogel fabrication
