Description
General Description
4-Arm PEG-Maleimide is a branched PEG derivative designed for thiol-specific bioconjugation and hydrogel formation. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced crosslinking efficiency, and improved network formation.
The terminal maleimide groups react rapidly and selectively with sulfhydryl-containing peptides, proteins, antibodies, polymers, nanoparticles, and biomaterials under mild aqueous conditions to form stable thioether linkages. This highly efficient thiol-maleimide chemistry is widely utilized in hydrogel fabrication, cell encapsulation, controlled drug delivery, tissue engineering, and protein immobilization applications.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption.
Applications
- Hydrogel synthesis
- Injectable hydrogels
- Tissue engineering
- Cell encapsulation
- Protein conjugation
- Peptide conjugation
- Antibody conjugation
- Drug delivery systems
- Surface modification
- Biomaterials research
Features and Benefits
- Four terminal maleimide groups
- Multi-arm PEG architecture
- Efficient thiol-specific conjugation
- Forms stable thioether linkages
- High crosslinking efficiency
- Excellent water solubility
- Excellent biocompatibility
- Low protein adsorption
- Available in multiple molecular weight
