Description
General Description
4-Arm PEG-Hydrazine is a branched PEG derivative designed for bioorthogonal conjugation and hydrogel formation. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced crosslinking efficiency, and improved network formation.
The terminal hydrazine groups react efficiently with aldehyde- and ketone-containing molecules under mild aqueous conditions to form hydrazone bonds. These linkages can exhibit pH-responsive behavior, making them attractive for controlled drug release and stimuli-responsive biomaterials.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption. 4-Arm PEG-Hydrazine is widely employed in injectable hydrogels, tissue engineering scaffolds, cell encapsulation, protein immobilization, drug delivery systems, and regenerative medicine applications.
Applications
- Hydrogel synthesis
- Injectable hydrogels
- Tissue engineering
- Cell encapsulation
- Drug delivery systems
- Protein conjugation
- Surface modification
- Biomaterials engineering
- Controlled release systems
- Biomedical research
Features and Benefits
- Four terminal hydrazine groups
- Multi-arm PEG architecture
- Reacts with aldehydes and ketones
- Forms hydrazone linkages
- Suitable for pH-responsive materials
- High crosslinking efficiency
- Excellent water solubility
- Excellent biocompatibility
- Available in multiple molecular weights
