Description
General Description
4-Arm PEG-SCM is a highly reactive branched PEG derivative designed for amine-specific bioconjugation and hydrogel formation. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced crosslinking efficiency, and increased loading capacity for biomolecules and therapeutic agents.
The terminal succinimidyl carboxymethyl ester groups react rapidly with primary amines on proteins, peptides, antibodies, enzymes, and biomaterial surfaces to form stable amide bonds. Compared with succinimidyl succinate derivatives, SCM esters generate more hydrolytically stable amide linkages and are widely employed in protein PEGylation and biomolecule modification.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption. 4-Arm PEG-SCM is frequently employed in protein modification, hydrogel fabrication, tissue engineering, cell encapsulation, drug delivery systems, and advanced biomaterials applications.
Applications
- Protein PEGylation
- Antibody conjugation
- Peptide conjugation
- Hydrogel synthesis
- Injectable hydrogels
- Tissue engineering
- Cell encapsulation
- Drug delivery systems
- Surface modification
- Biomaterials research
Features and Benefits
- Four terminal SCM ester groups
- Highly reactive toward primary amines
- Multi-arm PEG architecture
- Efficient amine-specific conjugation
- Forms stable amide bonds
- Excellent water solubility
- Excellent biocompatibility
- Low protein adsorption
- Available in multiple molecular weights
