Description
General Description
NH2-PEG-OH is a versatile heterobifunctional PEG linker designed for selective bioconjugation and polymer functionalization. The terminal primary amine reacts efficiently with NHS esters, activated carboxylic acids through EDC/NHS coupling, aldehydes, epoxides, isothiocyanates, and other electrophilic functional groups, enabling conjugation to proteins, peptides, antibodies, enzymes, polymers, nanoparticles, and biomaterial surfaces.
The terminal hydroxyl group serves as a convenient synthetic handle and can be readily converted into a wide range of functional groups, including carboxyl, NHS ester, maleimide, azide, alkyne, aldehyde, acrylate, methacrylate, epoxide, thiol, and many other PEG derivatives. This makes NH2-PEG-OH an important intermediate for the synthesis of customized heterobifunctional PEG linkers.
The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while reducing steric hindrance and minimizing nonspecific protein adsorption. NH2-PEG-OH is extensively employed in protein PEGylation, peptide synthesis, nanoparticle engineering, hydrogel preparation, targeted drug delivery, biosensor fabrication, and advanced biomaterials development.
Applications
- Protein PEGylation
- Antibody conjugation
- Peptide synthesis
- Polymer synthesis
- PEG linker synthesis
- Surface modification
- Nanoparticle functionalization
- Hydrogel synthesis
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Terminal primary amine
- Terminal hydroxyl group
- Efficient amine conjugation
- Versatile synthetic intermediate
- Excellent water solubility
- Excellent biocompatibility
- Reduced steric hindrance
- Low nonspecific protein adsorption
- Available in multiple PEG molecular weights
