Description
General Description
DSPE-PEG-COOH is a versatile lipid-PEG conjugate designed for membrane anchoring and biomolecule conjugation. The DSPE lipid anchor readily incorporates into liposomal membranes and lipid nanoparticle formulations, while the PEG spacer extends into the aqueous environment, improving colloidal stability, reducing nonspecific interactions, and enhancing circulation properties.
The terminal carboxylic acid group can be activated using EDC/NHS chemistry and subsequently conjugated with amine-containing peptides, proteins, antibodies, nucleic acids, fluorophores, and targeting ligands. DSPE-PEG-COOH is widely used in liposome engineering, targeted nanomedicine, diagnostic applications, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Nanomedicine research
- Diagnostic applications
- Biomolecule immobilization
Features and Benefits
- DSPE anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive carboxylic acid group for versatile conjugation
- Compatible with EDC/NHS coupling chemistry
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
Key Applications
- Preparation of long-circulating PEGylated liposomes
- Surface functionalization of lipid nanoparticles
- Targeted drug and gene delivery systems
- Covalent conjugation with biomolecules (via -COOH chemistry)
- Nanocarrier engineering for biomedical research
Functional Advantages
- Provides stable PEGylated lipid membranes
- Extends blood circulation time of nanocarriers
- Offers reactive carboxyl groups for further modification
- Enhances biocompatibility and reduces nonspecific adsorption
- Suitable for targeted delivery system design
Summary
DSPE-PEG-COOH is a functional lipid–PEG conjugate designed for stable, long-circulating liposomes with reactive carboxyl groups for downstream bioconjugation and targeted drug delivery applications.
