Description
General Description
4-Arm PLGA-COOH is a multifunctional biodegradable polyester designed for advanced drug delivery and biomedical applications. The polymer consists of four PLGA chains radiating from a central core, with each arm terminating in a reactive carboxyl group.
The carboxyl functionalities can be activated using EDC/NHS chemistry for conjugation to peptides, proteins, antibodies, targeting ligands, fluorophores, and other amine-containing biomolecules. The multi-arm architecture provides significantly higher functional group density than linear PLGA derivatives, enabling efficient preparation of targeted nanoparticles, crosslinked biomaterials, and multifunctional delivery systems.
Upon hydrolysis, the polymer degrades into lactic acid and glycolic acid, making it suitable for biodegradable medical and pharmaceutical applications.
Applications
- Drug delivery systems
- Polymeric nanoparticles
- Targeted drug delivery
- Peptide conjugation
- Antibody conjugation
- Hydrogel formation
- Controlled drug release
- Surface modification
- Tissue engineering
- Nanomedicine research
Features and Benefits
- Star-shaped PLGA architecture
- Multiple terminal carboxyl groups
- Higher functional group density than linear PLGA
- Biodegradable and biocompatible
- Compatible with EDC/NHS coupling chemistry
- Enhanced drug loading capability
- Suitable for nanoparticle and hydrogel fabrication
- Available in multiple molecular weights and PLGA ratios
