Description
General Description
Cholesterol-PEG-N₃ is a versatile lipid-PEG conjugate designed for nanoparticle surface engineering and bioorthogonal conjugation. The cholesterol anchor readily incorporates into liposomal membranes and lipid nanoparticle formulations, while the PEG spacer extends into the aqueous phase, improving colloidal stability and reducing nonspecific interactions.
The terminal azide group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, allowing attachment of peptides, proteins, antibodies, fluorophores, nucleic acids, and targeting ligands. Cholesterol-PEG-N₃ is commonly employed in targeted nanomedicine, diagnostic probes, and advanced lipid-based delivery systems.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Click chemistry conjugation
- Targeted drug delivery
- Surface modification
- Antibody conjugation
- Peptide conjugation
- Fluorescent probe preparation
- Nanomedicine research
- Diagnostic applications
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive azide group for click chemistry
- Compatible with CuAAC and SPAAC reactions
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
