Description
General Description
Cholesterol-PEG-Mal is a versatile lipid-PEG conjugate designed for membrane anchoring and biomolecule conjugation. The cholesterol segment readily inserts into liposomal membranes and lipid nanoparticle formulations, while the PEG chain extends into the aqueous environment, improving colloidal stability and reducing nonspecific interactions.
The terminal maleimide group reacts efficiently with sulfhydryl-containing peptides, proteins, antibodies, aptamers, and targeting ligands under mild conditions, forming stable thioether bonds. Cholesterol-PEG-Mal is widely used in targeted nanomedicine, liposome engineering, diagnostic applications, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Thiol-maleimide conjugation
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Nanomedicine research
- Diagnostic applications
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive maleimide group for selective thiol coupling
- Forms stable thioether linkages
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
