Description
General Description
Cholesterol-PEG-Vinyl Sulfone is a versatile lipid-PEG conjugate designed for membrane anchoring and thiol-specific conjugation. The cholesterol segment readily incorporates into liposomal membranes, lipid nanoparticles, micelles, and other lipid-based delivery systems, while the PEG spacer extends into the aqueous environment, improving colloidal stability, circulation properties, and reducing nonspecific interactions.
The terminal vinyl sulfone group reacts selectively with thiol-containing peptides, proteins, antibodies, and other biomolecules under mild conditions to form stable thioether linkages. Compared with maleimide chemistry, vinyl sulfone conjugates often exhibit enhanced hydrolytic stability. Cholesterol-PEG-Vinyl Sulfone is widely used in targeted nanomedicine, liposome engineering, diagnostic applications, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Targeted drug delivery
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Thiol-specific bioconjugation
- Surface modification
- Nanomedicine research
- Diagnostic applications
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive vinyl sulfone group for thiol conjugation
- Forms stable thioether linkages
- Compatible with peptides, proteins, and antibodies
- Improved hydrolytic stability compared with maleimide chemistry
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Available in multiple PEG molecular weights
