Description
General Description
DOPE is one of the most commonly used helper lipids in lipid-based drug delivery systems. The lipid contains two oleic acid chains attached to a glycerol backbone and a phosphoethanolamine head group. Unlike phosphatidylcholines, DOPE tends to adopt non-bilayer hexagonal (HII) phases, which facilitate membrane destabilization and fusion.
This unique property makes DOPE particularly valuable in gene delivery, mRNA delivery, siRNA delivery, liposome formulation, and lipid nanoparticle development. DOPE is frequently combined with cationic lipids, ionizable lipids, cholesterol, and PEG lipids to improve intracellular delivery efficiency.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- mRNA delivery
- siRNA delivery
- DNA transfection
- Gene therapy research
- Endosomal escape enhancement
- Drug delivery research
- Membrane fusion studies
- Nanomedicine development
Features and Benefits
- Widely used helper lipid
- Promotes membrane fusion
- Enhances endosomal escape
- Improves intracellular delivery efficiency
- Unsaturated C18:1 acyl chains
- Compatible with ionizable and cationic lipids
- Suitable for liposome and LNP formulations
- Excellent batch-to-batch consistency
Summary
DOPE is a versatile unsaturated phospholipid widely used in liposome engineering, lipid nanoparticle development, gene delivery, and advanced nanomedicine research applications.
