Description
General Description
DODAP (1,2-Dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid containing two oleoyl (C18:1) hydrocarbon chains and a tertiary amine headgroup. Due to its pH-responsive ionization behavior, DODAP is widely used in lipid nanoparticle (LNP) formulations for the encapsulation and intracellular delivery of nucleic acids.
DODAP-containing formulations can facilitate efficient RNA, DNA, siRNA, and oligonucleotide delivery while maintaining favorable biocompatibility and formulation stability.
Key Properties
- Ionizable cationic lipid
- Two oleoyl (C18:1) lipid chains
- pH-responsive ionization behavior
- Suitable for LNP and liposome formulation
- Efficient nucleic acid encapsulation
- Widely used in gene delivery research
Applications
- Lipid nanoparticle (LNP) formulations
- mRNA delivery
- siRNA delivery
- Gene therapy research
- Nucleic acid delivery
- Nanomedicine development
- Liposome formulation
Functional Overview
The ionizable amine group enables electrostatic interaction with nucleic acids during formulation while reducing positive surface charge at physiological pH. The dioleoyl lipid chains contribute to membrane fusion and intracellular delivery performance.
Summary
DODAP (18:1) is a well-established ionizable lipid widely used in lipid nanoparticle engineering, nucleic acid delivery, and advanced nanomedicine research.
